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What if you are a problem drinker or alcoholic, along with a medical professional could give you a drug to consider away your urge to drink—while you were still able to continue drinking? Advocates of this treatment approach, called the Sinclair method, claim you'd likely experience no withdrawal symptoms. According to proponents, after three or four months around the medication, all while still being able to continue to drink, you'd experience diminished cravings and even find that your urge to drink goes away completely. Using two separate drugs to lose weight can be very effective there are combinations while watching FDA now awaiting approval. When dealing with weight-loss and the individuals who go through it you need to err on the side of caution and let the FDA do its job and demand some study be done so your public knows the side effects and risks of the medications before we bring them. Keep in mind that drug companies are in business to generate income and that they would say almost anything to keep people on their own medications. Researchers found that participants using this drug to get a year, lost weight within one month and have kept the weight off through the entire 56 weeks in the study. Contrave can be a combination from the drugs naltrexone and bupropion, which appears to reflect a new trend of weight-loss drugs which might be made up of more than one active ingredient, which might make them far better and safer. Combo-pilling may be the newest fad or better yet the newest to come under scrutiny and for that reason it is just more publicly known in recent months, comb-pilling for losing weight has been around since the eighties. The biggest reason that utilizing a combination of pills is now popular may be the fact that by right now there aren't long term prescription slimming capsules that have been licensed by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications and some of the combinations are actually rejected or have yet to be approved by the FDA. Seizures can be a side effect with Contrave and must not be taken in individuals with seizure disorders. The drug can also raise blood pressure levels and heart rate, and mustn't be used in those with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise hypertension and heartrate and must 't be used in patients with uncontrolled high hypertension, along with by anyone with heart-related and cerebrovascular (circulation dysfunction impacting mental performance) disease. Patients having a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients on the increased chance of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for smoking cessation. Suboxone is made up of two drugs; buprenorphine and naloxone. The naloxone is irrelevant if your addict uses the medication properly, but when the tablet is dissolved in water and injected the naloxone may cause instant withdrawal. When suboxone is employed correctly, the naloxone is destroyed within the liver right after uptake from the intestines and it has no therapeutic effect. Buprenorphine is the active substance; it is absorbed underneath the tongue (and during the entire mouth) but destroyed by the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I have used this formulation if the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I have treated addicts who may have had gastric bypass, the place that the first the main intestine is bypassed and the stomach contents empty in to a more distal area of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the process with normal anatomy in which the drug is taken up from the duodenum and transferred straight away to the liver through the portal vein, where it is quickly and completely destroyed. After gastric bypass naloxone can be taken up by areas of the intestine which aren't served from the portal system, causing blood degrees of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.