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It must be used in combination with a low-calorie diet and frequent exercise in order to be effective. Using two separate drugs to shed weight can be very effective you'll find combinations before the FDA now awaiting approval. When dealing with fat loss and the people that go through it you ought to err on the side of caution and allow the FDA do its job and demand some research be done so the public is aware of the side effects and hazards of the medications before we take them. Keep in mind that drug companies are in business to earn money and that they would say anything to keep people on their own medications. Researchers found that participants taking this drug for any year, lost weight within one month and have kept the extra weight off during the entire 56 weeks from the study. Contrave can be a combination in the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs that are made up of multiple active ingredient, which can make them more effective and safer. Combo-pilling is the newest fad or in addition to this the newest into the future under scrutiny and for that reason it is just more publicly known lately, comb-pilling for weight reduction has been around since the eighties. The biggest reason that utilizing a combination of pills is becoming popular could be the fact that by right now there aren't any long term prescription weight loss supplements that have been licensed by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications even though some of the combinations are actually rejected or have yet to be approved by the FDA. Seizures really are a side effect with Contrave and mustn't be taken in individuals with seizure disorders. The drug can also raise blood pressure and pulse rate, and shouldn't be used in people who have a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure and pulse rate and must 't be used in patients with uncontrolled high hypertension, and also by a person with heart-related and cerebrovascular (circulatory dysfunction impacting mental performance) disease. Patients which has a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes having a boxed warning to alert medical professionals and patients for the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stop smoking. Most of the combinations that are used to enhance weight-loss involve an amphetamine with an antidepressant. Phentermine and Prozac are a popular combination which were around for quite a while, and although it has been around nobody wants to truly combine both the and try to get FDA approval to promote it as a weight-loss pill. Right there should raise some warning flags if the greedy pharmaceutical companies should not be involved in combining medications and selling them something should be wrong using the combination. In fairness there is one weight reduction combination pill that's in front of the FDA now Contrave?which couples naltrexone, utilized to treat alcohol and abusing drugs, while using antidepressant bupropion (Wellbutrin, Zyban) it has been given the try to move forward by an FDA advisory committee, but by yet is not approved.